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Second Son is set seven years after the good ending of Infamous 2, in which Cole MacGrath activated the Ray Field Inhibitor to destroy a Conduit named John White, also known as the Beast and cure the Plague. The explosion that resulted was originally thought to have killed all Conduits across the globe; however, those outside of the blast radius or with a natural resistance have survived.
Fearing the Conduits' abilities after the destruction of Empire City, the US eastern seaboard and the worldwide economy, the Department of Unified Protection is formed. Now, major cities across the United States are heavily monitored for Conduit activity, whom the DUP have labeled collectively as "bio-terrorists".
The game is set in Seattle, Washington, now under DUP jurisdiction. Players control Delsin Rowe, a 24 year-old slacker graffiti artist, who wants to help the community by protesting against the government, which he hates. Because his brother, Reggie, is a police officer, Delsin does not have a good connection with him, seeing as his brother has arrested him numerous times. After unknowingly helping a conduit out of the wreckage of a DUP truck, Delsin is attacked. He wakes up with 'powers' including the ability to use a smoke dash and later finds out he can use these powers offensively. Reggie wants to help Delsin find a cure for him being a conduit and helps him to fight back against the government.
Delsin then finds out that he can absorb other conduit's powers for his own use. These powers include smoke, neon, and video. The developers have said these powers are "the tip of the iceberg".
CLEARING MARKET - Infamous Second Son Walkthrough Evil w/ Nova Ep.10